Nature Reviews Neurology ( IF 38.1 ) Pub Date : 2017-11-17 , DOI: 10.1038/nrneurol.2017.139 Martin Stangel , Tanja Kuhlmann , Paul M. Matthews , Trevor J. Kilpatrick
Achievements and obstacles of remyelinating therapies in multiple sclerosis, Published online: 17 November 2017; doi:10.1038/nrneurol.2017.139
NatureArticleSnippet(type=short-summary, markup=Inadequate remyelination is central to degeneration and disability in patients with multiple sclerosis (MS); however, all currently approved therapies for MS are primarily immunomodulatory. Here, Martin Stangel and colleagues review our current knowledge of remyelination in MS, discuss results from clinical trials of remyelination-enhancing therapies, and evaluate the opportunities for future regenerative treatments.
中文翻译:
多发性硬化症中髓鞘再生疗法的成就和障碍
多发性硬化症中髓鞘再生疗法的成就和障碍
多发性硬化症中髓鞘再生疗法的成就和障碍,在线发布:2017年11月17日;doi:10.1038 / nrneurol.2017.139
NatureArticleSnippet(type = short-summary,markup =髓鞘再生不足是多发性硬化症(MS)患者变性和残疾的关键。但是,目前所有批准的MS治疗方法主要是免疫调节的。在这里,Martin Stangel及其同事回顾了我们目前对MS髓鞘再生的知识,讨论了增强髓鞘再生疗法的临床试验结果,并评估了未来再生疗法的机会。