As gonadotoxic adverse effects of antineoplastic treatments can result in infertility, gamete cryopreservation is routinely offered to patients as the strategy to preserve their fertility. However, there are many cases where gold standards cannot be applied, as is the case for prepubertal cancer patients and others unable to produce gametes or their precursors at the moment of diagnosis. With an increasing number of cancer survivors in our society, strategies using either cryopreserved gonadal tissue or stem cells have been developed to allow cancer survivors to achieve fatherhood, and recent advances in the field have increased public interest. In this review, we discuss the latest updates in fertility preservation from a basic and a clinical point of view.

由于抗肿瘤药的性腺毒性不良反应可导致不孕，因此通常向患者提供配子冷冻保存以作为保留其生育力的策略。但是，在许多情况下，如青春期前的癌症患者和其他在诊断时无法产生配子或其前体的患者，则无法应用黄金标准。随着我们社会中癌症幸存者数量的增加，已经开发了使用冷冻保存的性腺组织或干细胞的策略，以使癌症幸存者获得父亲身份，并且该领域的最新进展已引起了公众的关注。在这篇综述中，我们从基本和临床的角度讨论生育力保存的最新进展。