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Access to α-Amino Acid Esters through Palladium-Catalyzed Oxidative Amination of Vinyl Ethers with Hydrogen Peroxide as the Oxidant and Oxygen Source
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2017-11-17 05:15:50 , DOI: 10.1002/anie.201709285
Lu Ouyang 1 , Jianxiao Li 1 , Jia Zheng 1 , Jiuzhong Huang 1 , Chaorong Qi 1 , Wanqing Wu 1 , Huanfeng Jiang 1
Affiliation  

Start simple: Readily available amines and vinyl ethers were converted into highly functionalized and structurally diverse α-amino acid esters by the use of a convenient palladium catalytic system in which hydrogen peroxide acted as both a green oxidant and an oxygen-atom source (see scheme). This versatile strategy is characterized by the simplicity of the experimental procedure, mild reaction conditions, and high atom economy.

中文翻译:

通过过氧化氢作为氧化剂和氧源的钯催化乙烯基醚的氧化胺化反应获得α-氨基酸酯

从简单开始:通过使用方便的钯催化体系将现成的胺和乙烯基醚转化为高度官能化的和结构多样的α-氨基酸酯,其中过氧化氢既是绿色氧化剂,又是氧原子源(参见方案) )。这种通用策略的特点是实验过程简单,反应条件温和且原子经济性高。
更新日期:2017-11-17
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