A simple and highly efficient one‐pot, metal‐free approach has been developed for the synthesis of β‐carboline−pyrazole/−pyrazoline‐based molecular hybrids. The synthesis of C1‐tethered β‐carboline−(N‐acetyl)pyrazolines was achieved by using a cyclocondensation approach, whilst β‐carboline‐substituted pyrazoles were synthesized through an I₂‐mediated oxidative condensation reaction. This procedure provides easy access to biologically interesting di‐ and trisubstituted pyrazoles that are decorated with β‐carboline frameworks.

中文翻译：

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合成基于β-咔啉-吡唑的分子杂化物的快速方法

已经开发了一种简单高效的无金属单锅方法，用于合成基于β-咔啉-吡唑/-吡唑啉的分子杂合物。通过环缩合方法可以合成C1系链的β-咔啉-（N-乙酰基）吡唑啉，而β-咔啉取代的吡唑是通过I ₂介导的氧化缩合反应合成的。通过该程序，可以轻松获得生物学上有趣的用β-咔啉骨架修饰的二取代和三取代的吡唑。