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Sphingolipid metabolism in cancer signalling and therapy
Nature Reviews Cancer ( IF 78.5 ) Pub Date : 2017-11-17 , DOI: 10.1038/nrc.2017.96
Besim Ogretmen

Sphingolipid metabolism in cancer signalling and therapy

Sphingolipid metabolism in cancer signalling and therapy, Published online: 17 November 2017; doi:10.1038/nrc.2017.96

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Sphingolipids, specifically ceramide and sphingosine-1-phosphate, have opposing roles in regulating cancer cell death and survival, respectively. This Review discusses the mechanistic and clinical studies of sphingolipid signalling and metabolism in cancer, highlighting current and emerging therapeutic strategies to target these bioactive lipids.

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中文翻译:

鞘脂代谢在癌症信号传导和治疗中的作用

鞘脂代谢在癌症信号传导和治疗中的作用

鞘脂代谢在癌症信号传导和治疗中,在线发布:2017年11月17日; doi:10.1038 / nrc.2017.96

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鞘脂,特别是神经酰胺和鞘氨醇-1-磷酸,在调节癌细胞死亡和存活中分别具有相反的作用。这篇综述讨论了鞘脂信号传导和癌症代谢的机制和临床研究,重点介绍了针对这些生物活性脂质的当前和新兴治疗策略。

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更新日期:2017-11-17
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