In this work, the non-steroidal anti-inflammatory drugs ibuprofen (ibu) and ketoprofen (ket), both poorly soluble in water, were first intercalated into layered double hydroxide (LDH) nanoparticles. The drug–LDH composites were then mixed with poly(ε-caprolactone) (PCL) at 5% and 10% w/w ratios and processed into fibers via electrospinning, yielding organic–inorganic nanohybrids. PCL/drug fibers were additionally prepared as controls. The average diameter of the fibers ranged from 400 to 1000 nm. The fibers are found to be smooth and cylindrical, with the LDH-containing systems having more homogenous fibers than those without the inorganic filler. From in vitro drug release tests, it was determined that more than 90% of the intercalated ibu and ket were released from the drug–LDH nanohybrids within the first 4 hours. Similarly, more than 60% of the incorporated drug was freed from the PCL/drug fibers in this time period. However, the release rates of both ibu and ket from the drug–LDH loaded PCL fibers were significantly slower. Only 44–48% of ibu was released from the PCL/ibu–LDH system after 5 days, while the amount released in the case of ket was 20–25%. In addition, drug release was still ongoing after 5 days for all the PCL/drug–LDH samples. These systems are thus proposed to have potential as implantable drug delivery systems.

中文翻译：

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电纺有机-无机纳米杂化物作为缓释药物输送系统

在这项工作中，首先将非甾体抗炎药布洛芬（ibu）和酮洛芬（ket）溶于水，然后将它们插入层状双氢氧化物（LDH）纳米颗粒中。然后将药物-LDH复合材料与聚（ε-己内酯）（PCL）以5％和10％w / w的比例混合，并通过静电纺丝加工成纤维，从而产生有机-无机纳米杂化体。另外制备PCL /药物纤维作为对照。纤维的平均直径为400至1000nm。发现该纤维是光滑的和圆柱形的，与不含无机填料的那些相比，含LDH的系统具有更均匀的纤维。从体外通过药物释放测试，可以确定在最初的4小时内，有90％以上的嵌入的ibu和ket从药物-LDH纳米杂种中释放出来。同样，在这段时间内，超过60％的掺入药物从PCL /药物纤维中释放出来。但是，从载有LDH的PCL纤维中，ibu和ket的释放速率均明显较慢。5天后，只有44–48％的ibu从PCL / ibu–LDH系统中释放，而在ket情况下释放的量为20–25％。此外，所有PCL /药物-LDH样品在5天后仍在释放药物。因此，建议这些系统具有作为可植入药物输送系统的潜力。