N,N′-Bis(furan-2-ylmethyl)oxalamide (BFMO), an inexpensive and conveniently available bidentate ligand, is very effective for promoting Cu-catalyzed N-arylation of anilines and cyclic secondary amines. The method enables coupling of a broad range of (hetero)aryl bromides with various (hetero)aryl amines and cyclic secondary amines at 0.5–5 mol % catalyst loadings at relatively low temperatures. For coupling with more sterically hindered acyclic secondary amines, using N,N′-bis(2,4,6-trimethoxyphenyl)oxalamide (BTMPO) as a ligand gives the better results. Additionally, high selectivity is achieved in CuI/BFMO-catalyzed direct monoarylation of piperazine with (hetero)aryl bromides to afford pharmaceutically important building blocks.

中文翻译：

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N，N'-二异戊酰胺可增强（杂）芳基溴化物与苯胺和仲胺的铜催化偶联反应

N，N′-双（呋喃-2-基甲基）草酰胺（BFMO），一种廉价且方便获得的二齿配体，对于促进Cu催化的苯胺和环状仲胺的N-芳基化非常有效。该方法可以在相对较低的温度下以0.5-5 mol％的催化剂负载量将各种（杂）芳基溴化物与各种（杂）芳基胺和环状仲胺偶联。为了与更受空间阻碍的无环仲胺偶联，可使用N，N以'-双（2,4,6-三甲氧基苯基）草酰胺（BTMPO）为配体可获得更好的结果。另外，在CuI / BFMO催化的哌嗪与（杂）芳基溴化物直接单芳基化中获得了高选择性，从而获得了重要的药学组成部分。