The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism.

中文翻译：

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等位利巴韦林类似物：合成和抗病毒活性

通过两种不同的方式合成了新型的等位性利巴韦林类似物。其中一些对丙型肝炎病毒（HCV），单纯疱疹（HCV-1）和A型流感病毒显示了与病毒唑本身相当的抗病毒作用。获得的数据证实了与生物等位基因有关的利巴韦林可能的抗病毒活性机制的理论建议。