In this paper, synthesis and characterization of metal complexes [Cu₂(L)₃]ClO₄ (1), [Ga(L)₂]NO₃·2H₂O (2) and [In(L)₂]NO₃·H₂O (3) (HL = 2-acetylpyridine N(4)-phenylthiosemicarbazone) was carried out, including elemental analysis, spectral analysis (IR, UV-vis, NMR), and X-ray crystallography. Complex 1 contains one S-bridged binuclear [Cu₂(L)₃]⁺ unit, where two Cu atoms display diverse coordination geometries: one being square planar geometry and the other octahedral geometry. Both 2 and 3 are mononuclear complexes, and the metal centers in 2 and 3 are chelated by two NNS tridentate ligands possessing a distorted octahedral geometry. Biological studies show that all the complexes possess a wide spectrum of modest to effective antibacterial activities and remarkable cytotoxicities against HepG2 cells, and 1, in particular, with an IC₅₀ value of 0.19 ± 0.06 μM, is 113-fold and 28-fold more cytotoxic than HL and the antitumor drug mitoxantrone, respectively. In addition, 3 exhibits excellent photoluminescence properties. Upon the addition of 1 equiv of In³⁺ ions, a remarkable fluorescence intensity of HL and fluorescent color change (from transparent to light-green) could be observed with 365 nm light, indicating that this ligand may be used as a promising colorimetric and fluorescent probe for In³⁺ detection.

中文翻译：

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2-乙酰基吡啶N（4）-苯基硫代半碳脲的Cu（II），Ga（III）和In（III）配合物：合成，光谱表征和生物学活性

本文研究了金属配合物[Cu ₂（L）₃ ] ClO ₄（1），[Ga（L）₂ ] NO ₃ ·2H ₂ O（2）和[In（L）₂ ] NO _3的合成与表征。·进行了H ₂ O（3）（HL = 2-乙酰基吡啶N（4）-苯基硫代半碳zone），包括元素分析，光谱分析（IR，UV-vis，NMR）和X射线晶体学。配合物1包含一个S桥联双核[Cu ₂（L）₃ ] ⁺单位，其中两个Cu原子显示不同的配位几何形状：一个是正方形平面几何形状，另一个是八面体几何形状。既2和3是单核配合物，并且在金属中心2和3是由两个NNS螯合三齿配体具有一个扭曲的八面体几何形状。生物学研究表明，所有复合物均具有广谱的中等至有效的抗菌活性以及对HepG2细胞的显着细胞毒性，其中1尤其是IC ₅₀值为0.19±0.06μM，分别为113倍和28倍。细胞毒性分别比HL和抗肿瘤药米托蒽醌。另外3表现出优异的光致发光性能。加入1当量的In ³⁺离子，可以在365 nm的光下观察到HL的显着荧光强度和荧光颜色变化（从透明到浅绿色），这表明该配体可以用作有前途的比色法和用于In ³⁺检测的荧光探针。