Sustainability in chemical synthesis is a major aspect of the current synthetic endeavors and, therefore, mimicking the biological process in the laboratory nowadays has the highest priority. Towards achieving this goal, designing organic reactions in domino mode rather than the multistep synthetic pathways and using organocatalysis instead of metal catalysis have received a lot of attention due to the inherent advantages of these processes in terms of synthetic efficiency and sustainability. As a result, the field of asymmetric organocatalytic domino reactions has witnessed tremendous progress in recent years. This review attempts to summarize the latest developments in asymmetric organocatalyzed domino reactions since 2012, with the emphasis on the catalysts and reaction modes. Discussions on the reaction mechanisms and the applications of the developed domino reaction methods in the synthesis of biologically active molecules and natural products are also included when appropriate.

中文翻译：

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有机催化不对称多米诺转化的最新进展

化学合成的可持续性是当前合成努力的主要方面，因此，如今，在实验室中模仿生物过程已成为当务之急。为了实现该目标，由于这些方法在合成效率和可持续性方面的固有优势，因此以多米诺骨牌模式而不是多步合成途径设计有机反应并使用有机催化代替金属催化受到了广泛的关注。结果，近年来，不对称有机催化多米诺反应领域已经取得了巨大进展。这篇综述试图总结自2012年以来不对称有机催化多米诺骨牌反应的最新进展，重点是催化剂和反应模式。