The process of angiogenesis, involving generation of new blood vessels from the existing ones, is vital for the supply of oxygen and nutrients to various tissues of body system. Angiogenesis is directly associated with several physiological and pathological processes. It is well-established that impairment in angiogenesis process results in various fatal conditions. Recently, few research groups including ours demonstrated therapeutic angiogenesis through nanomedicine approach using metal oxide/hydroxide nanoparticles. However, there is still a thorough necessity for the development of novel, eco-friendly, pro-angiogenic nanomaterials. Hence, in the present study we demonstrate the in vitro and in vivo pro-angiogenic properties of terbium hydroxide nanorods (THNRs) synthesized using an advanced microwave irradiation method, along with the detailed molecular signaling cascade underlying THNRs induced angiogenesis. The in vivo wound healing and nonimmunogenicity of the THNRs have been validated in the mouse models. We thus strongly believe that the present study establishing the pro-angiogenic properties of THNRs will aid in the development of alternative treatment strategies for wound healing along with cardiovascular and ischemic diseases, where angiogenesis is the chief target.

中文翻译：

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氢氧化b纳米棒的促血管生成特性：在伤口愈合中的分子机理及其治疗应用

涉及从现有血管生成新血管的血管生成过程对于向身体系统的各个组织供应氧气和营养至关重要。血管生成与几种生理和病理过程直接相关。众所周知，血管生成过程的损伤会导致各种致命的状况。最近，包括我们在内的几乎没有研究小组通过使用金属氧化物/氢氧化物纳米粒子的纳米药物方法证明了治疗性血管生成。然而，仍然需要开发新型的，生态友好的，促血管生成的纳米材料。因此，在本研究中，我们证明了使用先进的微波辐射方法合成的氢氧化hydroxide纳米棒（THNRs）的体外和体内促血管生成特性，以及潜在的THNRs引起的详细的分子信号传导级联反应诱导了血管生成。THNR的体内伤口愈合和非免疫原性已在小鼠模型中得到验证。因此，我们坚信，建立THNRs促血管生成特性的本研究将有助于开发以血管生成为主要靶点的替代疗法，用于治疗伤口愈合以及心血管和缺血性疾病。