Two-dimensional (2D) J-resolved NMR technique offers a natural solution for disentangling complex mixtures that suffer from crowded spectra in 1D NMR. The applicability of classical 2D J-resolved spectroscopy is inevitably limited by phase-twist lineshapes and strong coupling artifacts. Here, a general and robust NMR method is proposed to record 2D absorption-mode J-resolved spectra in rapid acquisition manner. This method can also reduce the impact of strong coupling artifacts, thus achieving full considerations for applications. Intuitively, this method delivers pure chemical shifts along one dimension and orthogonally adds J couplings along the other dimension, free of 45° spectral shearing. It may provide a powerful tool for structural and configurational studies as well as biological analyses.

中文翻译：

---

通用二维吸收模式J分辨NMR光谱

二维（2D）J分辨NMR技术为解缠复杂的混合物提供了自然的解决方案，这些复杂的混合物在1D NMR中拥挤了光谱。经典2D J分辨光谱的适用性不可避免地受到相位扭曲线形和强耦合伪像的限制。在此，提出了一种通用且鲁棒的NMR方法来以快速采集的方式记录2D吸收模式的J分辨谱。该方法还可以减少强耦合伪影的影响，从而充分考虑了应用程序。直观地讲，此方法沿一维传递纯化学位移，并正交添加J沿其他尺寸的联轴器，无45°光谱剪切。它可能为结构和构型研究以及生物学分析提供强大的工具。