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pH/Ultrasound Dual‐Responsive Gas Generator for Ultrasound Imaging‐Guided Therapeutic Inertial Cavitation and Sonodynamic Therapy
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-11-15 , DOI: 10.1002/adhm.201700957
Qianhua Feng 1, 2 , Wanxia Zhang 1 , Xuemei Yang 1 , Yuzhen Li 1 , Yongwei Hao 1, 2 , Hongling Zhang 1, 2 , Lin Hou 1, 2, 3 , Zhenzhong Zhang 1, 2, 3
Affiliation  

Herein, a pH/ultrasound dual‐responsive gas generator is reported, which is based on mesoporous calcium carbonate (MCC) nanoparticles by loading sonosensitizer (hematoporphyrin monomethyl ether (HMME)) and modifying surface hyaluronic acid (HA). After pinpointing tumor regions with prominent targeting efficiency, HMME/MCC‐HA decomposes instantaneously under the cotriggering of tumoral inherent acidic condition and ultrasound (US) irradiation, concurrently accompanying with CO2 generation and HMME release with spatial/temporal resolution. Afterward, the CO2 bubbling and bursting effect under US stimulus results in cavitation‐mediated irreversible cell necrosis, as well as the blood vessel destruction to further occlude the blood supply, providing a “bystander effect.” Meanwhile, reactive oxygen species generated from HMME can target the apoptotic pathways for effective sonodynamic therapy. Thus, the combination of apoptosis/necrosis with multimechanisms consequently results in a remarkable antitumor therapeutic efficacy, simultaneously minimizing the side effects on major organs. Moreover, the echogenic property of CO2 make the nanoplatform as a powerful ultrasound contrast agent to identify cancerous lesions. Based on the above findings, such all‐in‐one drug delivery platform of HMME/MCC‐HA is utilized to provide the US imaging guidance for therapeutic inertial cavitation and sonodynamic therapy simultaneously, which highlights possibilities of advancing cancer theranostics in biomedical fields.

中文翻译:

pH /超声双响应气体发生器,用于超声成像引导的惯性空化和声动力学治疗

本文中报道了一种pH /超声波双响应气体发生器,它基于中孔碳酸钙(MCC)纳米颗粒,通过负载声敏剂(血卟啉单甲醚(HMME))和改性表面透明质酸(HA)来实现。在以显着的靶向效率精确定位肿瘤区域后,HMME / MCC-HA在肿瘤固有酸性条件和超声(US)辐射的作用下瞬间分解,同时伴随着CO 2的产生和具有时空分辨率的HMME的释放。之后,CO 2在美国刺激下的起泡和破裂作用会导致空化介导的不可逆细胞坏死,并破坏血管以进一步阻塞血液供应,从而产生“旁观者效应”。同时,从HMME产生的活性氧可以靶向细胞凋亡途径,以进行有效的声动力学治疗。因此,凋亡/坏死与多种机制的组合因此导致显着的抗肿瘤治疗功效,同时使对主要器官的副作用最小化。此外,CO 2的回声特性使纳米平台成为一种强大的超声造影剂,可用于识别癌性病变。基于以上发现,这种HMME / MCC‐HA一体式药物输送平台可为惯性空化和声动力学治疗同时提供美国成像指导,这凸显了在生物医学领域推进癌症治疗学的可能性。
更新日期:2017-11-15
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