Based on the linear peptides that have an affinity for EGFR extracellular domain, cyclic peptides with enhanced affinity and stability were designed. Cyclic peptides exhibited serum stability and binding to EGFR protein. Such peptides can be conjugated with fluorescent labels for imaging EGFR-overexpressed colon cancer.

中文翻译：

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靶向EGFR胞外域的肽配体：线性和环状肽之间的比较

基于对EGFR胞外域具有亲和力的线性肽，设计了具有增强的亲和力和稳定性的环肽。环肽显示出血清稳定性并与EGFR蛋白结合。可以将此类肽与荧光标记物偶联，以对EGFR过表达的结肠癌进行成像。