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Bioluminescence probe for γ-glutamyl transpeptidase detection in vivo
Bioorganic & Medicinal Chemistry ( IF 3.5 ) Pub Date : 2017-11-14 , DOI: 10.1016/j.bmc.2017.11.025
Yuxing Lin , Yuqi Gao , Zhao Ma , Tianyu Jiang , Xin Zhou , Zhenzhen Li , Xiaojun Qin , Yun Huang , Lupei Du , Minyong Li

To detect γ-Glutamyl Transpeptidase (GGT) activity in vitro and in vivo, a bioluminescence probe with high sensitivity and specificity was well designed and synthesized. This probe can be recognized by GGT and release strong bioluminescence with its further reaction with luciferase. The performance of this probe was demonstrated in vitro and in cells. Finally, we applied the probe for detection of GGT activity in xenograft model.



中文翻译:

用于体内γ-谷氨酰转肽酶检测的生物发光探针

为了检测体内和体外的γ-谷氨酰转肽酶(GGT)活性,精心设计和合成了具有高灵敏度和特异性的生物发光探针。该探针可被GGT识别,并通过与荧光素酶的进一步反应释放强烈的生物发光。在体外和细胞中证明了该探针的性能。最后,我们将探针应用于异种移植模型中GGT活性的检测。

更新日期:2017-11-14
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