Elaborately designed novel multifunctional therapeutic agents are highly desired for efficient cancer therapy. In this work, a new therapeutic nanoplatform based on calcium phosphate/small gold nanorod assemblies modified with methoxy-poly(ethylene glycol)-thiol (designated as PEGylated CaP/Au NR assemblies) is created via a mild, reproducible, and simple route for the first time. The obtained PEGylated CaP/Au NR assemblies possess many virtues including outstanding drug-loading capacity, excellent photothermal conversion efficiency (η, ∼38.5%), pH/near-infrared (NIR) dual-responsive release property, and good biocompatibility. After loading doxorubicin (DOX) in PEGylated CaP/Au NR assemblies, the DOX-loaded PEGylated CaP/Au NR assemblies can simultaneously supply intense heating effect and increased DOX release under 808 nm NIR laser, achieving excellent antitumor therapeutic effect in vitro and in vivo. Furthermore, the combination of DOX-loading and photothermal treatment upon PEGylated CaP/Au NR assemblies displays better therapeutic effect than single chemotherapy or photothermal therapy. Furthermore, the comprehensive methyl thiazolyl tetrazolium (MTT), hemolysis, and histological assays manifest no obvious toxicity of PEGylated CaP/Au NR assemblies. Our work elucidates the great prospect of PEGylated CaP/Au NR assemblies as a therapeutic agent for synergistic chemo-photothermal cancer therapy.

中文翻译：

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合理设计的磷酸钙/小金纳米棒组件，以聚（丙烯酸钙盐）纳米球为模板，用于化学光热联合癌症治疗

精心设计的新型多功能治疗剂是有效进行癌症治疗的高度期望。在这项工作中，通过温和，可复制且简单的途径，创建了一种新的基于磷酸钙/金纳米棒组件的新型治疗性纳米平台，该组件经甲氧基-聚（乙二醇）-硫醇修饰（称为PEG化CaP / Au NR组件）。第一次。获得的聚乙二醇化CaP / Au NR组件具有许多优点，包括出色的载药量，出色的光热转化效率（η，约38.5％），pH /近红外（NIR）双重响应释放特性和良好的生物相容性。将阿霉素（DOX）装入PEG化CaP / Au NR组件后，在808 nm NIR激光下，装有DOX的PEG化CaP / Au NR组件可同时提供强烈的加热效果并增加DOX的释放，在体外和体内均具有出色的抗肿瘤治疗效果。此外，与单一化学疗法或光热疗法相比，在聚乙二醇化的CaP / Au NR组件上进行DOX负载和光热处理的组合显示出更好的治疗效果。此外，全面的甲基噻唑基四唑（MTT），溶血和组织学分析表明，聚乙二醇化CaP / Au NR组件无明显毒性。我们的工作阐明了聚乙二醇化CaP / Au NR组装作为协同化学光热癌症治疗的治疗剂的广阔前景。全面的甲基噻唑基四唑（MTT），溶血和组织学分析表明，聚乙二醇化CaP / Au NR组装件无明显毒性。我们的工作阐明了聚乙二醇化CaP / Au NR组装作为协同化学光热癌症治疗的治疗剂的广阔前景。全面的甲基噻唑基四唑（MTT），溶血和组织学分析表明，聚乙二醇化CaP / Au NR组装件无明显毒性。我们的工作阐明了聚乙二醇化CaP / Au NR组装作为协同化学光热癌症治疗的治疗剂的广阔前景。