An improved system for the synthesis of N-acyl amino acids via Pd-catalyzed amidocarbonylation is reported. Utilizing inexpensive Pd black gives the industrially important surfactant N-lauroyl sarcosine in excellent yields (95%) on a multi-gram scale. Advantages of the new system include reusability, decreased process temperature, and, importantly, drastically decreased co-catalyst loading.

中文翻译：

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酰胺羰基化法合成N-月桂酰肌氨酸的比较：均相和多相钯催化剂

报道了一种通过Pd催化的酰胺羰基化合成N-酰基氨基酸的改进系统。使用便宜的钯黑可以以克为单位，以极高的收率（95％）提供工业上重要的表面活性剂N-月桂酰肌氨酸。新系统的优势包括可重复使用性，降低的工艺温度，以及重要的是，大大降低了助催化剂的负载量。