1,6-Conjugated addition-mediated [4 + 1] annulation: an approach to 2,3-dihydrobenzofurans,Organic Chemistry Frontiers

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1,6-Conjugated addition-mediated [4 + 1] annulation: an approach to 2,3-dihydrobenzofurans
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2017-11-07 00:00:00 , DOI: 10.1039/c7qo00846e
Lina Liu _{1,

2,

3,

4,

5} , Zhenbo Yuan _{1,

2,

3,

4,

5} , Rui Pan _{1,

2,

3,

4,

5} , Yuye Zeng _{1,

2,

3,

4,

5} , Aijun Lin _{1,

2,

3,

4,

5} , Hequan Yao _{1,

2,

3,

4,

5} , Yue Huang _{3,

4,

5,

6,

7}

Affiliation

A formal 1,6-conjugated addition-mediated [4 + 1] annulation of ortho-hydroxyphenyl-substituted para-quinone methides with sulfonium or ammonium bromides has been described. This domino-type process offered an efficient method for the synthesis of 2,3-dihydrobenzofurans in good yields, exhibiting good functional group tolerance, scalability and high diastereoselectivity.

中文翻译：

1,6-共轭加成介导的[4 +1]环空：一种2,3-二氢苯并呋喃的方法

已经描述了正式的1，6-共轭加成介导的[4- + 1]邻-羟基苯基取代的对-醌甲基化物与sulf或溴化铵的环合。这种多米诺型工艺提供了一种高效，高收率地合成2,3-二氢苯并呋喃的方法，具有良好的官能团耐受性，可扩展性和高非对映选择性。

更新日期：2017-11-15

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