The functions and unique features of long intergenic non-coding RNA

The functions and unique features of long intergenic non-coding RNA, Published online: 15 November 2017; doi:10.1038/nrm.2017.104

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Long intergenic non-coding RNAs (lincRNAs) do not overlap protein-coding genes, although some lincRNA genes have minimal coding potential and can include small open reading frames that encode functional peptides. lincRNA functions include RNA stabilization and transcription regulation and the remodelling of chromatin and genome architecture. Recent insights suggest that lincRNAs broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity.

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中文翻译：

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长的基因间非编码RNA的功能和独特特征

长的基因间非编码RNA的功能和独特特征

较长的基因间非编码RNA的功能和独特特征，在线发布：2017年11月15日; doi：10.1038 / nrm.2017.104

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长的基因间非编码RNA（lincRNA）不会与蛋白质编码基因重叠，尽管某些lincRNA基因具有最小的编码潜力，并且可以包含小的编码功能性肽的开放阅读框。lincRNA功能包括RNA稳定和转录调控以及染色质和基因组结构的重塑。最近的见解表明，lincRNA广泛用于微调具有显着组织特异性的邻近基因的表达。

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