Not just a four-helix bundle: The use of a diiron-binding four-helix bundle scaffold with an asymmetric active site leads to an enhancement in selectivity of the iron-catalyzed oxidative coupling of phenols. The stabilization of the oxidized intermediate in the binding pocket enables the net four-electron O₂ reduction, without release of any detectable H₂O₂.

中文翻译：

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De Novo异源二聚体铁蛋白可最大程度地减少依赖于双氧的氧化反应中的中间体的释放

不仅是四螺旋束：具有不对称活性位点的二铁结合四螺旋束支架的使用会导致铁催化的酚氧化偶联的选择性增强。结合口袋中被氧化的中间体的稳定化使得四电子O ₂净减少，而不会释放任何可检测的H ₂ O ₂。