Increased concentrations of eosinophils in blood and sputum in chronic obstructive pulmonary disease (COPD) have been associated with increased frequency of exacerbations, reduced lung function, and corticosteroid responsiveness. We aimed to assess whether high eosinophil concentrations in either sputum or blood are associated with a severe COPD phenotype, including greater exacerbation frequency, and whether blood eosinophils are predictive of sputum eosinophils.

中文翻译：

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痰液和血液中嗜酸性粒细胞浓度与COPD严重程度的临床指标的关联：对SPIROMICS队列的分析。

慢性阻塞性肺疾病（COPD）中血液和痰中嗜酸性粒细胞浓度的增加与病情加重，肺功能下降和皮质类固醇反应性增加有关。我们旨在评估痰或血液中嗜酸性粒细胞浓度高是否与严重的COPD表型相关，包括加剧发作频率，以及血液嗜酸性粒细胞是否可预测痰嗜酸性粒细胞。