Lincomycin mycelial residue (LMR) is the restricted resource because it contains residual lincomycin, which is producing potential risks to the environment and human health. In this study, lincomycin-degrading strain LCM-B was isolated and identified as Clostridium sp. in the LMR. Strain LCM-B was able to degrade 62.03% of lincomycin at the initial concentration of 100 mg L⁻¹ after incubation for 10 d, while only 15.61% of lincomycin was removed at the initial concentration of 500 mg L⁻¹. The removal efficiency of lincomycin by strain LCM-B decreased as the initial concentration increased. Gene lnuB (which encodes the nucleotidyl transferase) was detected in the isolated strain, and it was proven to participate in lincomycin biodegradation based on the analysis of degradation products and pathway. The results provide a relatively complete understanding of lincomycin biodegradation mechanism. Strain LCM-B is promising to eliminate lincomycin from the LMR.

林可霉素菌丝体残留物（LMR）是受限制的资源，因为它含有残留的林可霉素，对环境和人类健康产生潜在的风险。在这项研究中，林可霉素降解菌LCM-B被分离并鉴定为梭菌属。在LMR中。孵育10天后，菌株LCM-B在100 mg L ^-1的初始浓度下能降解62.03％的林可霉素，而在500 mg L ^-1的初始浓度下仅能去除15.61％的林可霉素。。LCM-B菌株对林可霉素的去除效率随初始浓度的增加而降低。在分离的菌株中检测到基因lnuB（编码核苷酸转移酶），并通过降解产物和途径的分析证明其参与了林可霉素的生物降解。结果提供了对林可霉素生物降解机理的相对完整的理解。LCM-B菌株有望从LMR中消除林可霉素。