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Inflammation and Atherosclerosis
Circulation ( IF 37.8 ) Pub Date : 2017-11-14 , DOI: 10.1161/circulationaha.117.030484
Göran K. Hansson 1
Affiliation  

Does inflammation matter in coronary artery disease? Is it a driving force in atherosclerosis or merely an epiphenomenon? Is there space for novel therapies besides those targeting cholesterol? The CANTOS trial (Canakinumab Anti-inflammatory Thrombosis Outcomes Study), which was presented at the European Society of Cardiology meeting in Barcelona a few weeks ago, provides answers to these important questions. Indeed, the results of this trial open up a new avenue for cardiovascular prevention.

Atherosclerosis, the underlying pathology in most cases of myocardial infarction, ischemic stroke, and ischemic gangrene, is a disease of complex genesis that has remained controversial for decades. Clinical and experimental studies have provided unequivocal evidence for an etiologic role of cholesterol and also offered strong support for a pathogenic role of inflammation.1

By targeting cholesterol, blood pressure, and cigarette smoking, cardiovascular prevention has become one of the great success stories in medicine. We have witnessed a reduction in the incidence of myocardial infarction by ≈40% in large parts of the world during the past 2 decades, and a substantial part of this decrease can be ascribed to preventive medicine.1 Cholesterol-lowering statin therapy reduces the incidence of major adverse cardiovascular events by 25% to 50% in individuals with elevated low-density lipoprotein cholesterol and has become standard therapy for …



中文翻译:

炎症和动脉粥样硬化

炎症对冠状动脉疾病有影响吗?它是动脉粥样硬化的驱动力还是仅仅是表象现象?除了针对胆固醇的疗法以外,还有其他新颖疗法的空间吗?几周前在巴塞罗那举行的欧洲心脏病学会会议上发表的CANTOS试验(Canakinumab抗炎性血栓形成结果研究)为这些重要问题提供了答案。确实,该试验的结果为心血管预防开辟了新途径。

动脉粥样硬化是大多数心肌梗塞,缺血性中风和缺血性坏疽的潜在病理学,是一种复杂的起源疾病,数十年来一直引起争议。临床和实验研究为胆固醇的病因学作用提供了明确的证据,也为炎症的致病作用提供了有力的支持。1个

通过针对胆固醇,血压和吸烟,心血管预防已成为医学上的巨大成功案例之一。在过去的20年中,我们见证了世界上大部分地区心肌梗塞的发生率降低了约40%,其中很大一部分原因可归功于预防医学。1降低他汀类药物的胆固醇治疗可将低密度脂蛋白胆固醇升高的个人的主要不良心血管事件发生率降低25%至50%,已成为……的标准疗法。

更新日期:2017-11-14
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