Human primary liver cancer–derived organoid cultures for disease modeling and drug screening,Nature Medicine

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Human primary liver cancer–derived organoid cultures for disease modeling and drug screening
Nature Medicine ( IF 82.9 ) Pub Date : 2017-11-13 , DOI: 10.1038/nm.4438
Laura Broutier , Gianmarco Mastrogiovanni , Monique MA Verstegen , Hayley E Francies , Lena Morrill Gavarró , Charles R Bradshaw , George E Allen , Robert Arnes-Benito , Olga Sidorova , Marcia P Gaspersz , Nikitas Georgakopoulos , Bon-Kyoung Koo , Sabine Dietmann , Susan E Davies , Raaj K Praseedom , Ruby Lieshout , Jan N M IJzermans , Stephen J Wigmore , Kourosh Saeb-Parsy , Mathew J Garnett , Luc JW van der Laan , Meritxell Huch

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening, Published online: 13 November 2017; doi:10.1038/nm.4438

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Tumor organoids derived from the most common subtypes of primary liver cancer recapitulate the histologic and molecular features of the tissues of origin, even after long-term culture. These in vitro models, as well as those for colorectal cancer reported in Crespo et al. in a previous issue, are amenable for drug screening and allow the identification of therapeutic approaches with potential for cancer treatment.

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