Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies

Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies, Published online: 13 November 2017; doi:10.1038/nm.4444

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Pule and colleagues identify the TCR β-chain constant region as a new target for chimeric antigen receptor (CAR) T cells in treatment of T cell cancers while potentially preserving a healthy T cell repertoire. They demonstrate that anti-TCRB1 CAR T cells eliminate cancerous TCRB1⁺ T cells while sparing nearly one-third of normal TCRB2⁺ T cells.

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中文翻译：

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靶向T细胞受体β链恒定区用于T细胞恶性肿瘤的免疫治疗

靶向T细胞受体β链恒定区用于T细胞恶性肿瘤的免疫治疗

靶向T细胞受体β链恒定区用于T细胞恶性肿瘤的免疫治疗，在线发布：2017年11月13日; doi：10.1038 / nm.4444

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Pule及其同事将TCRβ链恒定区确定为嵌合抗原受体（CAR）T细胞在治疗T细胞癌症中的新靶标，同时潜在地保留了健康的T细胞库。他们证明抗TCRB1 CAR T细胞可消除癌性TCRB1 ⁺ T细胞，而几乎保留正常TCRB2 ⁺ T细胞的三分之一。

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