Top-down characterization of endogenous protein complexes with native proteomics,Nature Chemical Biology

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Top-down characterization of endogenous protein complexes with native proteomics
Nature Chemical Biology ( IF 14.8 ) Pub Date : 2017-11-13 , DOI: 10.1038/nchembio.2515
Owen S Skinner , Nicole A Haverland , Luca Fornelli , Rafael D Melani , Luis H F Do Vale , Henrique S Seckler , Peter F Doubleday , Luis F Schachner , Kristina Srzentić , Neil L Kelleher , Philip D Compton

Top-down characterization of endogenous protein complexes with native proteomics

Top-down characterization of endogenous protein complexes with native proteomics, Published online: 13 November 2017; doi:10.1038/nchembio.2515

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A multistage tandem mass spectrometry approach enables the application of native proteomics to characterize intact endogenous protein complexes in discovery mode, including covalent modifications as well as noncovalently bound cofactors and ligands.

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