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Amphiphilic small peptides for delivery of plasmid DNAs and siRNAs
Chemical Biology & Drug Design ( IF 3 ) Pub Date : 2017-11-13 01:12:01 , DOI: 10.1111/cbdd.13122
Eun-Kyoung Bang 1 , Hanna Cho 2 , Sean S.-H. Jeon 2 , Na Ly Tran 1, 3 , Dong-Kwon Lim 2 , Wooyoung Hur 1 , Taebo Sim 1, 2
Affiliation  

As novel nucleic acid carriers, linear and branched amphiphilic peptides were prepared. Each peptide was compared in terms of SNALP size, stability, and delivery activities for plasmid DNA (pDNA) and siRNA. Among the five peptides, a linear peptide H-RCL was an effective delivery carrier for both siRNA and pDNA. Introduction of a benzoyl group to H-RCL significantly enhanced siRNA delivery but greatly reduced pDNA delivery. These demonstrated that a small structural modification of the peptides can modulate their delivery properties.

中文翻译:

两亲小肽,用于传递质粒DNA和siRNA

作为新型核酸载体,制备了线性和分支的两亲性肽。比较了每种肽的SNALP大小,稳定性和质粒DNA(pDNA)和siRNA的递送活性。在这五种肽中,线性肽H-RCL是siRNA和pDNA的有效传递载体。在H-RCL中引入苯甲酰基可显着增强siRNA的传递,但会大大降低pDNA的传递。这些证明了肽的小的结构修饰可以调节其递送性质。
更新日期:2017-11-13
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