In this issue of Cancer Cell, Pathania et al. report sporadic childhood histone K27M mutant malignant glioma mouse models that faithfully recapitulate the human tumor phenotypes. Beyond emphasizing the importance of correct timing in mouse modeling of cancer, these models will facilitate research to effectively treat this lethal childhood cancer.

中文翻译：

---

庞廷婴儿胶质瘤简化。

在本期《癌细胞》中，Pathania等人。报道了忠实地概括人类肿瘤表型的散发性儿童期组蛋白K27M突变型恶性神经胶质瘤小鼠模型。除了强调正确的时机在癌症小鼠模型中的重要性外，这些模型还将有助于进行研究以有效治疗这种致命的儿童期癌症。