Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14.

中文翻译：

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早期GalNAc O糖基化：推动肿瘤边界。

糖基化改变经常在癌细胞中观察到并影响肿瘤的进展。在本期《癌细胞》中，Nguyen等人。结果表明，GALNT1从高尔基体向内质网的迁移驱动肝脏肿瘤的生长和侵袭，这是由于糖基化作用增强以及细胞外基质降解金属蛋白酶MMP14的相应激活所致。