A new coordination complex, namely, [Zn₇L₂(HL)₂(OH⁻)₄(H₂O)₂]·2H₂O (1) [H₃L = 3′-nitro-biphenyl-3,5,4′-tricarboxylic acid] was synthesized by a solvothermal reaction. Complex 1 has a 3D open framework with heptanuclear cluster [Zn₇O2(OH)4] secondary building units (SBUs) and features an unexpected large porous structure with a pore size of 16.5 × 19.5 Ų, which shows 37.0% porosity as calculated by PLATON. Adenosine triphosphate disodium salt (ATP), adenosine-5′-diphosphate disodium salt (ADP), guanosine 5′-triphosphate (GTP), or uridine 5′-triphosphate (UTP) was discriminated from other phosphate anions using fluorescence spectral analysis by adjusting the excitation wavelength at 287, 287, 306, or 337 nm. Complex 1 showed fluorescence sensing of ATP, ADP, GTP, and UTP in aqueous solution. In addition, complex 1 also exhibited a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), with a loading content of 46.5 wt%, and presented a slow controlled drug release.

中文翻译：

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基于3'-硝基联苯-3,5,4'-三羧酸的具有大通道的Zn（II）配合物：水溶液中ATP，ADP，GTP和UTP的合成，晶体结构，荧光传感和药物递送

一种新的配位络合物，即，[锌₇大号₂（HL）₂（OH ^- ）₄（H ₂ O）₂ ]·2H ₂ O（1）[H ₃ L = -3'-硝基联苯-3,5-通过溶剂热反应合成[4，-三羧酸]。复杂1具有heptanuclear簇[Zn组成的三维开放的框架₇ ]次级结构单元（的SBU），并设有一个意想不到的大的多孔结构16.5×19.5埃的孔径²O2(OH)4，根据PLATON计算，其显示出37.0％的孔隙度。使用荧光光谱分析，通过调节荧光光谱，将三磷酸腺苷钠（ATP），5'-二磷酸腺苷钠（ADP），5'-三磷酸鸟苷（UTP）或尿苷5'-三磷酸钠（UTP）与其他磷酸根阴离子区分开。激发波长为287、287、306或337 nm。配合物1在水溶液中显示出对ATP，ADP，GTP和UTP的荧光感应。另外，复合物1还显示出显着的抗癌药物5-氟尿嘧啶（5-FU）的能力，其负载量为46.5重量％，并且呈现出缓慢受控的药物释放。