Cellular senescence constitutes a stable growth arrest characterized by DNA damage response (DDR) activation and by the senescence-associated secretory phenotype (SASP). SASP, through its paracrine effects, stimulates the immune system for senescence eradication. Similarly, chemotherapy-treated cancers activate an interferon-mediated response to induce anti-tumor immunity. Recent studies now uncover a new role for the innate DNA sensing pathway in the recognition of cytosolic chromatin in senescence and cancer.

中文翻译：

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感知断裂：衰老和癌症中的胞质染色质

细胞衰老构成稳定的生长停滞，其特征在于DNA损伤反应（DDR）激活和衰老相关的分泌表型（SASP）。SASP通过其旁分泌作用刺激免疫系统以消除衰老。同样，化学疗法治疗的癌症会激活干扰素介导的反应，从而诱导抗肿瘤免疫力。现在的最新研究揭示了先天性DNA传感途径在衰老和癌症中识别细胞质染色质中的新作用。