There remains an unmet dermatological need for innovative topical agents that achieve better longterm outcomes with fewer side effects. Modulation of the expression and activity of microRNA (miRNAs) represents an emerging translational framework for the development of such innovative therapies because changes in the expression of one miRNA can have wide-ranging effects on diverse cellular processes associated with disease. In this short review, the roles of miRNA in epidermal development, psoriasis, cutaneous squamous cell carcinoma and re-epithelisation are highlighted. Consideration is given to the delivery of oligonucleotides that mimic or inhibit miRNA function using vehicles such as cell penetrating peptides, spherical nucleic acids, deformable liposomes and liquid crystalline nanodispersions. Formulation of miRNA-directed oligonucleotides with such skin-penetrating epidermal agents will drive the development of RNA-based cutaneous therapeutics for deployment as primary or adjuvant therapies for epidermal disorders.

皮肤病学对创新的局部用药的需求仍未得到满足，这些新型局部用药可实现更好的长期疗效且副作用更少。微小RNA（miRNA）的表达和活性的调节代表了这种创新疗法发展的新兴翻译框架，因为一种miRNA的表达变化可对与疾病相关的多种细胞过程产生广泛影响。在这篇简短的综述中，着重指出了miRNA在表皮发育，牛皮癣，皮肤鳞状细胞癌和再上皮形成中的作用。考虑使用载体例如细胞穿透肽，球形核酸，可变形脂质体和液晶纳米分散体来递送模拟或抑制miRNA功能的寡核苷酸。