Carbohydrate Polymers ( IF 11.2 ) Pub Date : 2017-11-08 , DOI: 10.1016/j.carbpol.2017.10.095 Mariana Ioniță , Livia Elena Crică , Stefan Ioan Voicu , Sorina Dinescu , Florin Miculescu , Marieta Costache , Horia Iovu
Comparative evaluation of innovative combinations of three types of carbon nanomaterial (CNM) highlighted membranes with important potential for biomedical applications. Non-solvent induced phase separation coupled with ultrasound technique was used to generate membranes comprised of (i) cellulose acetate/ammonia functionalized carbon nanotubes (CA/CNT), (ii) cellulose acetate/ammonia functionalized graphene oxide (CA/GO), and (iii) cellulose acetate/CNT-GO. Structural, topographical and thermal features as well as water and ethanol permeation, bovine serum albumin (BSA) and haemoglobin (Hb) rejection were evaluated. Biocompatibility in terms of cytotoxicity, cell proliferation and adhesion were explored using a 3T3E1 cell line. The formation of amorphous structures, within which the CNMs were well dispersed, facilitated the development of smoother topographies. Addition of CNMs generated morphological changes influencing a decrease in water and ethanol fluxes. Furthermore, CNMs concentrated within the membrane skin layer exhibited repellent effects against BSA and Hb molecules and excellent cytocompatibility.
中文翻译:
碳纳米管和石墨烯在生物医学应用中对高性能醋酸纤维素膜的协同作用
三种类型的碳纳米材料(CNM)的创新组合的比较评估突出了具有生物医学应用潜力的膜。非溶剂诱导的相分离与超声技术相结合,用于生成膜,该膜由(i)醋酸纤维素/氨水官能化的碳纳米管(CA / CNT),(ii)醋酸纤维素/氨水官能化的氧化石墨烯(CA / GO)和(iii)醋酸纤维素/ CNT-GO。评估了结构,地形和热学特征以及水和乙醇的渗透性,牛血清白蛋白(BSA)和血红蛋白(Hb)的排斥率。使用3T3E1细胞系探索了在细胞毒性,细胞增殖和粘附方面的生物相容性。CNM很好地分散在其中的无定形结构的形成促进了更平滑地形的发展。加入CNM会产生影响水和乙醇通量减少的形态变化。此外,浓缩在膜皮层内的CNM对BSA和Hb分子表现出驱避作用,并具有出色的细胞相容性。