Abstract

β-Ketonitriles are an important class of compounds in the field of organic and medicinal chemistry. Over the past decades, numerous efforts have been devoted to the development of new and efficient methodologies for the synthesis of these derivatives, and a number of efficient methods to accomplish this have been developed in recent years. In this context, this short review highlights recent advances in the synthesis of β-ketonitriles.

1 Introduction

2 Acylation of Alkyl Nitriles

3 Electrophilic Cyanation of Ketone Enolates

4 Electrophilic Cyanation of β-Keto Carbonyl Compounds

5 Transition-Metal-Catalyzed Carbonylative Coupling Reactions

6 Miscellaneous Examples

7 Outlook

β-Ketonitriles are an important class of compounds in the field of organic and medicinal chemistry. Over the past decades, numerous efforts have been devoted to the development of new and efficient methodologies for the synthesis of these derivatives, and a number of efficient methods to accomplish this have been developed in recent years. In this context, this short review highlights recent advances in the synthesis of β-ketonitriles.

1 Introduction

2 Acylation of Alkyl Nitriles

3 Electrophilic Cyanation of Ketone Enolates

4 Electrophilic Cyanation of β-Keto Carbonyl Compounds

5 Transition-Metal-Catalyzed Carbonylative Coupling Reactions

6 Miscellaneous Examples

7 Outlook

中文翻译：

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β-乙腈合成的最新进展

摘要

β-乙腈是有机和药物化学领域中的重要一类化合物。在过去的几十年中，已经为开发用于合成这些衍生物的新的有效方法进行了许多努力，并且近年来已经开发了许多用于实现这些目的的有效方法。在这种情况下，这篇简短的评论着重介绍了β-酮腈合成的最新进展。

1引言

2烷基腈的酰化

3酮烯醇盐的亲电氰化

4β-酮羰基化合物的亲电氰化

5过渡金属催化的羰基化偶联反应

6个其他例子

7展望

β-乙腈是有机和药物化学领域中的重要一类化合物。在过去的几十年中，已经为开发用于合成这些衍生物的新的有效方法进行了许多努力，并且近年来已经开发了许多用于实现这些目的的有效方法。在这种情况下，这篇简短的评论着重介绍了β-酮腈合成的最新进展。

1引言

2烷基腈的酰化

3酮烯醇盐的亲电氰化

4β-酮羰基化合物的亲电氰化

5过渡金属催化的羰基化偶联反应

6个其他例子

7展望