Abstract

A novel, simple, and highly efficient method has been designed for the synthesis of ω-substituted arylbiurets in a one-pot reaction. The primary features of this protocol include readily available starting materials, an easy work-up procedure, and yields of 51 to 87%. ω-Substituted arylbiurets can be selectively prepared with an excess of potassium cyanate (KOCN). However, use of an excess of glacial acetic acid (AcOH) switches the reaction towards the formation of N-monosubstituted urea.

A novel, simple, and highly efficient method has been designed for the synthesis of ω-substituted arylbiurets in a one-pot reaction. The primary features of this protocol include readily available starting materials, an easy work-up procedure, and yields of 51 to 87%. ω-Substituted arylbiurets can be selectively prepared with an excess of potassium cyanate (KOCN). However, use of an excess of glacial acetic acid (AcOH) switches the reaction towards the formation of N-monosubstituted urea.

中文翻译：

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从芳香胺，氰酸钾和冰醋酸对ω取代的芳基缩二脲进行一锅法组装

摘要

设计了一种新颖，简单，高效的方法，用于在一个反应​​釜中合成ω-取代的芳基缩二脲。该协议的主要特征包括容易获得的起始原料，简单的后处理程序以及51％至87％的产率。ω-取代的芳基缩二脲可以用过量的氰酸钾（KOCN）选择性制备。但是，使用过量的冰醋酸（AcOH）会使反应转向形成N-单取代的尿素。

设计了一种新颖，简单，高效的方法，用于在一个反应​​釜中合成ω-取代的芳基缩二脲。该协议的主要特征包括容易获得的起始原料，简单的后处理程序以及51％至87％的产率。ω-取代的芳基缩二脲可以用过量的氰酸钾（KOCN）选择性制备。但是，使用过量的冰醋酸（AcOH）会使反应转向形成N-单取代的尿素。