Abstract

Azides obtained from Baylis–Hillman adducts were treated with triphenylphosphine to give the corresponding iminophosphoranes, which reacted with carbon disulfide at 40 °C to produce isothiocyanates. The reaction of these isothiocyanates with primary amines provided thiourea intermediates, which in the presence of potassium carbonate or sodium methoxide were converted into 2-thioxo-2,3-dihydropyrimidin-4(1H)-ones in good yields.

Azides obtained from Baylis–Hillman adducts were treated with triphenylphosphine to give the corresponding iminophosphoranes, which reacted with carbon disulfide at 40 °C to produce isothiocyanates. The reaction of these isothiocyanates with primary amines provided thiourea intermediates, which in the presence of potassium carbonate or sodium methoxide were converted into 2-thioxo-2,3-dihydropyrimidin-4(1H)-ones in good yields.

中文翻译：

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从Baylis–Hillman加合物合成2-硫代-2,3-二氢嘧啶-4（1H）-的新有效化合物

摘要

用三苯基膦处理从Baylis-Hillman加合物获得的叠氮化物，得​​到相应的亚氨基正膦，该亚氨基正膦在40°C下与二硫化碳反应生成异硫氰酸酯。这些异硫氰酸酯与伯胺的反应提供了硫脲中间体，该中间体在碳酸钾或甲醇钠存在下以良好的产率转化为2-硫代-2-3，3-二氢嘧啶-4（1H）-一。

用三苯基膦处理从Baylis-Hillman加合物获得的叠氮化物，得​​到相应的亚氨基正膦，该亚氨基正膦在40°C下与二硫化碳反应生成异硫氰酸酯。这些异硫氰酸酯与伯胺的反应提供了硫脲中间体，该中间体在碳酸钾或甲醇钠存在下以良好的产率转化为2-硫代-2-3，3-二氢嘧啶-4（1H）-一。