Abstract

A cascade C–H functionalization/C(sp³)–C(sp³) formation/cyclization reaction of N-methoxybenzamides with diazomal­onates under rhodium(III) catalysis is developed for the efficient synthesis of isoquinolinedione derivatives. A plausible mechanism involving double migratory insertions of carbenes for the formation of C(sp²)–C(sp³) and C(sp³)–C(sp³) bonds by rhodium(III) catalysis is also proposed.

A cascade C–H functionalization/C(sp³)–C(sp³) formation/cyclization reaction of N-methoxybenzamides with diazomal­onates under rhodium(III) catalysis is developed for the efficient synthesis of isoquinolinedione derivatives. A plausible mechanism involving double migratory insertions of carbenes for the formation of C(sp²)–C(sp³) and C(sp³)–C(sp³) bonds by rhodium(III) catalysis is also proposed.

中文翻译：

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Rh（III）催化的级联C–H官能化/ C（sp3）–C（sp3）形成/环化反应合成异喹啉二酮衍生物

摘要

在铑（III）催化下，N-甲氧基苯甲酰胺与重氮丙二酸酯的级联C–H功能化/ C（sp ³）–C（sp ³）形成/环化反应被开发用于有效合成异喹啉二酮衍生物。还提出了一种可能的机制，该机制涉及通过铑（III）催化碳二烯双迁移插入形成C（sp ²）–C（sp ³）和C（sp ³）–C（sp ³）键。

在铑（III）催化下，N-甲氧基苯甲酰胺与重氮丙二酸酯的级联C–H功能化/ C（sp ³）–C（sp ³）形成/环化反应被开发用于有效合成异喹啉二酮衍生物。还提出了一种可能的机制，该机制涉及通过铑（III）催化碳二烯双迁移插入形成C（sp ²）–C（sp ³）和C（sp ³）–C（sp ³）键。