Abstract

An efficient strategy for the synthesis of various of α,β-unsaturated γ-amino acid esters has been established employing N-heterocyclic carbene catalyzed [4+2] cycloadditions of β-methyl enals and aromatic nitroso compounds to afford 1,2-oxazin-6-ones in good yields. A subsequent acid-catalyzed esterification under ring opening yields the γ-amino enoates in good yields.

An efficient strategy for the synthesis of various of α,β-unsaturated γ-amino acid esters has been established employing N-heterocyclic carbene catalyzed [4+2] cycloadditions of β-methyl enals and aromatic nitroso compounds to afford 1,2-oxazin-6-ones in good yields. A subsequent acid-catalyzed esterification under ring opening yields the γ-amino enoates in good yields.

中文翻译：

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N-杂环卡宾催化[4 + 2]环烯和亚硝基化合物的环加成反应，两步合成α，β-不饱和γ-氨基酸酯

摘要

已经建立了一种有效的合成各种α，β-不饱和γ-氨基酸酯的策略，采用N-杂环卡宾催化的[4 + 2]环加成的β-甲基烯醛和芳族亚硝基化合物提供1,2-恶嗪-6个，高产。在开环下随后的酸催化的酯化以良好的产率产生γ-氨基烯酸酯。

已经建立了一种有效的合成各种α，β-不饱和γ-氨基酸酯的策略，采用N-杂环卡宾催化的[4 + 2]环加成的β-甲基烯醛和芳族亚硝基化合物提供1,2-恶嗪-6个，高产。在开环下随后的酸催化的酯化以良好的产率产生γ-氨基烯酸酯。