Published as part of the Bürgenstock Special Section 2017 Future Stars in Organic Chemistry

Abstract

By combining an iron-catalyzed borrowing hydrogen of allylic alcohols with an enantioselective organocatalyzed Michael addition of β-keto esters followed by a subsequent DBU-promoted lactonization different enantioenriched δ-lactones have been synthesized with good enantioselectivities. The valuable building blocks, featuring in some cases challenging quaternary stereocenters, have been obtained with >90% ee.

By combining an iron-catalyzed borrowing hydrogen of allylic alcohols with an enantioselective organocatalyzed Michael addition of β-keto esters followed by a subsequent DBU-promoted lactonization different enantioenriched δ-lactones have been synthesized with good enantioselectivities. The valuable building blocks, featuring in some cases challenging quaternary stereocenters, have been obtained with >90% ee.

中文翻译：

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β-酮酯和烯丙醇的多催化对映选择氢δ-内酯化策略

作为Bürgenstock专栏2017年有机化学中的未来之星的一部分发布

抽象的

通过将铁催化的烯丙醇的借入氢与β-酮酯的对映选择性有机催化的迈克尔加成反应相结合，随后进行DBU促进的内酯化，合成了具有良好对映选择性的各种对映体富集的δ-内酯。ee大于90％时，已经获得了有价值的构件，在某些情况下具有挑战性的四元立体中心。

通过将铁催化的烯丙醇的借入氢与β-酮酯的对映选择性有机催化的迈克尔加成反应相结合，随后进行DBU促进的内酯化，合成了具有良好对映选择性的各种对映体富集的δ-内酯。ee大于90％时，已经获得了有价值的构件，在某些情况下具有挑战性的四元立体中心。