Proteins that control cell cycle progression also drive multiciliated cell differentiation Multiciliated cells (MCCs) are a specialized population of postmitotic cells that are decorated with tens to hundreds of hairlike protrusions, termed motile cilia, that beat back and forth to direct fluid flow across an epithelium (1). MCCs line the respiratory tract, brain ventricles, and reproductive tracts of vertebrates and play a crucial role in tissue homeostasis; defects in the formation or movement of motile cilia can cause fertility defects, chronic respiratory infections, and/or a buildup of fluid in the brain. Despite their importance to human health, the pathways controlling the production of motile cilia in differentiating MCCs remain poorly understood. On page 803 of this issue, Al Jord et al. (2) shed light on this question by showing that multiciliated progenitor cells implement components of the mitotic cell cycle machinery to coordinate events that are required for motile ciliation and cellular differentiation, while avoiding cell division (mitosis).

中文翻译：

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多纤毛发生中的细胞周期蛋白月光

控制细胞周期进程的蛋白质也驱动多纤毛细胞分化 多纤毛细胞 (MCC) 是一种特殊的有丝分裂后细胞群，它们装饰有数十到数百个毛发状突起，称为运动纤毛，它们来回跳动以引导流体流过上皮(1). MCC 排列在脊椎动物的呼吸道、脑室和生殖道中，在组织稳态中起着至关重要的作用；运动纤毛形成或运动的缺陷可导致生育缺陷、慢性呼吸道感染和/或脑内积液。尽管它们对人类健康很重要，但在分化 MCC 中控制运动纤毛产生的途径仍然知之甚少。在本期第 803 页上，Al Jord 等人。