How can an innate immune sensor shape viral evolution? In recent work, Takata et al. (2017) determined that the antiviral protein ZAP recognizes CG dinucleotide composition to differentiate self from non-self. This pressure may have driven CG dinucleotide suppression in HIV-1 and other RNA viruses to evade host antiviral defenses.

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先天性免疫传感器如何塑造病毒进化？在最近的工作中，高田等人。（2017）确定抗病毒蛋白ZAP识别CG二核苷酸成分以区分自身和非自身。这种压力可能已导致HIV-1和其他RNA病毒中CG二核苷酸的抑制，从而逃避了宿主的抗病毒防御。