A recent study shows that the protumorigenic guanine nucleotide exchange factor (GEF) Vav1 functions as a tumor suppressor in T cell acute lymphoblastic leukemia (T-ALL) through its ability to complex with the Cbl-b ubiquitin ligase and the intracellular domain of Notch1 (ICN1) and to promote ICN1 degradation. Vav1can act as a double-edged sword in tumorigenesis.

中文翻译：

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Vav1：癌症的朋友和敌人

最近的一项研究表明，促癌性鸟嘌呤核苷酸交换因子（GEF）Vav1通过与Cbl-b泛素连接酶和Notch1的胞内结构域复合的能力，在T细胞急性淋巴细胞白血病（T-ALL）中起到抑癌作用。 ICN1）并促进ICN1降解。Vav1可以在肿瘤发生中充当一把双刃剑。