Water-soluble homopolypeptides bearing di(ethylene glycol) (DEG) linkages and various ionic liquid (IL) pendants with both lower and upper critical solution temperature (LCST and UCST) or a UCST were prepared and systematically investigated. Poly (γ-2-(2-chloroethoxy)ethyl _l-glutamate) (PCEELG) with DEG linkage and reactive chloro groups can be readily prepared from ring-opening polymerization of γ-2-(2-chloroethoxy)ethyl _l-glutamic acid based N-carboxyanhydride. Homopolypeptides were conjugated with various IL pendants and counteranions by nucleophilic substitutions and subsequent ion-exchange reactions. Homopolypeptide with DEG linkages and tributylphosphonium iodide (PEELG-TBP-I) showed interesting LCST < UCST (i.e., soluble-insoluble-soluble) dual thermoresponsive behavior in DI-H₂O and NaI aqueous solutions. The LCST-type and UCST-type phase transition temperatures (T_pts) were tunable by polymer concentration, molar mass, and NaI concentration. Homopolypeptide with DEG linkages and tributylphosphonium tetrafluoroborate showed a UCST both in DI-H₂O and PBS buffer while homopolypeptide with DEG linkages and triphenylphosphonium iodide (or tetrafluoroborate) or with alkyl linkages and tributylphosphonium iodide (or tetrafluoroborate) showed a UCST in PBS buffer. The UCST-type T_pt in PBS buffer was in a broad temperature range of 20–90 °C which was tunable by adjusting the polymer concentration, molar mass, IL moieties, and counteranions.

制备了带有双（乙二醇）（DEG）键和具有上下临界溶液温度（LCST和UCST）或UCST的各种离子液体（IL）侧基的水溶性均多肽，并进行了系统的研究。聚（γ -2-（2-氯乙氧基）乙基_升-谷氨酸）（PCEELG）与DEG键和反应性氯基团可以从开环聚合而容易地制备γ -2-（2-氯乙氧基）乙基_升谷氨酸基于N-羧基酐。通过亲核取代和随后的离子交换反应，将同多肽与各种IL侧基和抗衡阴离子缀合。具有DEG键的同多肽和碘化三丁基with（PEELG-TBP-1）在DI-H ₂ O和NaI水溶液中显示出有趣的LCST <UCST（即，可溶-不溶-可溶）双重热响应行为。LCST型和UCST型的相变温度（T _pt s）可通过聚合物浓度，摩尔质量和NaI浓度进行调节。具有DEG键的同多肽和四氟硼酸三丁基phosph在DI-H _2中均显示UCSTO和PBS缓冲液，而带有DEG键和碘化三苯基phosph（或四氟硼酸酯）或带有烷基键和碘化三丁基phosph（或四氟硼酸酯）的同多肽在PBS缓冲液中显示UCST。PBS缓冲液中的UCST型T _pt在20-90°C的较宽温度范围内，可通过调节聚合物浓度，摩尔质量，IL部分和抗衡阴离子来调节。