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Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer
Nature Chemical Biology ( IF 14.8 ) Pub Date : 2017-10-30 , DOI: 10.1038/nchembio.2510 Yi Qu , Jan Roger Olsen , Xing Yuan , Phil F Cheng , Mitchell P Levesque , Karl A Brokstad , Paul S Hoffman , Anne Margrete Oyan , Weidong Zhang , Karl-Henning Kalland , Xisong Ke
Nature Chemical Biology ( IF 14.8 ) Pub Date : 2017-10-30 , DOI: 10.1038/nchembio.2510 Yi Qu , Jan Roger Olsen , Xing Yuan , Phil F Cheng , Mitchell P Levesque , Karl A Brokstad , Paul S Hoffman , Anne Margrete Oyan , Weidong Zhang , Karl-Henning Kalland , Xisong Ke
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer
中文翻译：
小分子在癌症中促进β-catenin瓜氨酸化并抑制Wnt信号传导
小分子在癌症中促进β-catenin瓜氨酸化并抑制Wnt信号传导
更新日期：2017-11-10
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer, Published online: 30 October 2017; doi:10.1038/nchembio.2510
NatureArticleSnippet(type=short-summary, markup=The small molecule nitazoxanide (NTZ) was identified as a Wnt inhibitor by promoting protein citrullination of β-catenin through increased cytosolic calcium and PAD2 protein stabilization. β-catenin citrullination results in proteasomal degradation.
中文翻译：
小分子在癌症中促进β-catenin瓜氨酸化并抑制Wnt信号传导
小分子在癌症中促进β-catenin瓜氨酸化并抑制Wnt信号传导
小分子可促进β-catenin瓜氨酸化并抑制癌症中的Wnt信号传导，在线发布：2017年10月30日；doi：10.1038 / nchembio.2510
NatureArticleSnippet（type = short-summary，markup =通过提高胞质钙和PAD2蛋白质的稳定性来促进β-catenin的蛋白质瓜氨酸化，小分子硝唑尼特（NTZ）被鉴定为Wnt抑制剂。β-catenin瓜氨酸化可导致蛋白酶体降解。
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