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A CRISPR screen identifies a pathway required for paraquat-induced cell death
Nature Chemical Biology ( IF 14.8 ) Pub Date : 2017-10-23 , DOI: 10.1038/nchembio.2499
Colleen R Reczek , Kıvanç Birsoy , Hyewon Kong , Inmaculada Martínez-Reyes , Tim Wang , Peng Gao , David M Sabatini , Navdeep S Chandel

A CRISPR screen identifies a pathway required for paraquat-induced cell death

A CRISPR screen identifies a pathway required for paraquat-induced cell death, Published online: 23 October 2017; doi:10.1038/nchembio.2499

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A positive-selection CRISPR screen with the pro-oxidant paraquat (PQ) uncovers three genes mediating PQ-induced cell death: POR is the source of PQ-mediated reactive oxygen species (ROS) generation, and ATP7A and SLC45A4 promote oxidant-dependent cell death.

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中文翻译:

CRISPR筛选确定百草枯诱导的细胞死亡所需的途径

CRISPR筛选确定百草枯诱导的细胞死亡所需的途径

CRISPR屏幕可识别百草枯诱导的细胞死亡所需的途径,在线发布:2017年10月23日;doi:10.1038 / nchembio.2499

NatureArticleSnippet(type = short-summary,markup =

具有百草枯促氧化剂(PQ)的正选择CRISPR筛选发现了三种介导PQ诱导的细胞死亡的基因: POR 是PQ介导的活性氧(ROS)生成的来源,并且 ATP7ASLC45A4 促进氧化剂依赖性细胞死亡。

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更新日期:2017-11-10
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