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Hormesis as a mechanistic approach to understanding herbal treatments in traditional Chinese medicine
Pharmacology & Therapeutics ( IF 13.5 ) Pub Date : 2017-11-08 , DOI: 10.1016/j.pharmthera.2017.10.013
Dali Wang , Edward J. Calabrese , Baoling Lian , Zhifen Lin , Vittorio Calabrese

Traditional Chinese medicine (TCM) has been long practiced and is becoming ever more widely recognized as providing curative and/or healing treatments for a number of diseases and physiological conditions. This paper posits that herbal medicines used in TCM treatments may act through hormetic dose-response mechanisms. It is proposed that the stimulatory (i.e., low dose) and inhibitory (i.e., high dose) components of the hormetic dose response correspond to respective “regulating” and “curing” aspects of TCM herbal treatments. Specifically, the “regulating” functions promote adaptive or preventive responses, while “curing” treatments alleviate the clinical symptoms. Patterns of hormetic responses are described, and the applicability of these processes to herbal medicines of TCM are explicated. It is noted that a research agenda aimed at elucidating these mechanisms and patterns would be expansive and complex. However, we argue its value, in that hormesis may afford something akin to a Rosetta Stone with which to interpret, translate, and explain TCM herbology in ways that are aligned with biomedical perspectives that could enable a more integrative approach to medicine.



中文翻译:

增效疗法是了解中药草药疗法的一种机械方法

传统中医药(TCM)已被长期实践,并被越来越广泛地认为可为多种疾病和生理状况提供治疗和/或康复治疗。本文认为,中药治疗中所用的草药可能通过药物的剂量反应机制起作用。建议刺激性的(低剂量)和抑制性的(低剂量)。剂量响应中的“高剂量”部分对应于中药草药治疗的各个“调节”和“治愈”方面。具体而言,“调节”功能可促进适应性或预防性反应,而“治愈”疗法可缓解临床症状。描述了霍尔效应反应的模式,并阐明了这些过程对中草药的适用性。应当指出,旨在阐明这些机制和模式的研究议程将是广泛而复杂的。但是,我们认为它的价值在于,兴奋剂可能提供某种类似于Rosetta Stone的方式,用它来解释,翻译和解释TCM草药学,并使其与生物医学观点相一致,从而使医学方法更具综合性。

更新日期:2017-11-08
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