Mucosal administration of drugs and drug delivery systems has gained increasing interest. However, nanoparticles intended to protect and deliver drugs to epithelial surfaces require transport through the surface-lining mucus. Translation from bench to bedside is particularly challenging for mucosal administration since a variety of parameters will influence the specific barrier properties of the mucus including the luminal fluids, the microbiota, the mucus composition and clearance rate, and the condition of the underlying epithelia. Besides, after administration, nanoparticles interact with the mucosal components, forming a biomolecular corona that modulates their behavior and fate after mucosal administration. These interactions are greatly influenced by the nanoparticle properties, and therefore different designs and surface-engineering strategies have been proposed. Overall, it is essential to evaluate these biomolecule-nanoparticle interactions by complementary techniques using complex and relevant mucus barrier matrices.

药物和药物递送系统的粘膜给药越来越引起人们的兴趣。然而，旨在保护药物并将其递送至上皮表面的纳米颗粒需要通过表面衬里的粘液进行运输。从板凳到床边的平移对于粘膜给药特别具有挑战性，因为各种参数将影响粘液的特定屏障特性，包括腔液，微生物群，粘液成分和清除率以及底层上皮的状况。此外，给药后，纳米颗粒与粘膜成分相互作用，形成生物分子电晕，该信号分子调节粘膜给药后的行为和命运。这些相互作用受到纳米粒子特性的极大影响，因此，已经提出了不同的设计和表面工程策略。总体而言，至关重要的是通过使用复杂且相关的粘液屏障基质的互补技术来评估这些生物分子-纳米颗粒之间的相互作用。