Monodispersed chitosan-capped bimetallic nanoparticles (BNPs) of AgGd have been synthesized for “cancer theranosis” through environmentally benign microwave-assisted polyol synthesis. In the present article, we report the one-pot synthesis of AgGd BNPs with varied Ag:Gd molar ratios via coreduction of Ag⁺ and Gd³⁺ ions. Studies reveal a well-dispersed AgGd BNPs of average size 12 nm and also the presence of face-centered cubic (FCC) Ag and cubic Gd components within the individual crystal. Chitosan (CS) a biopolymer, as a capping agent facilitates the bioconjugation of doxorubicin (Dox), a potential anticancer drug on the surface of BNPs. The Dox was covalently conjugated onto the BNPs through pH-sensitive hydrazone linkage with CS. In vitro study reveals negligible drug release at physiological pH while release rate accelerates in acidic medium. The mutual properties of the host metals in AgGd BNPs at the nanoscale offer concurrent magnetic resonance imaging (MRI) and computed tomography (CT) contrast performances. Moreover, the paramagnetic behavior inherited by Gd in BNPs demonstrates both T₁ and T₂ contrast ability. BNPs ensures biocompatibility and also express sturdy therapeutic effects in HeLa cells when conjugated with Dox.

中文翻译：

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阿霉素结合的双金属银–纳米合金用于多峰MRI-CT光学成像和pH响应药物释放

已经通过环境友好的微波辅助多元醇合成合成了单分散的壳聚糖封端的AgGd双金属纳米颗粒（BNP），用于“癌症治疗”。在本文中，我们报道了通过Ag ⁺和Gd ^3+的共感应作用，一锅法合成具有不同Ag：Gd摩尔比的AgGd BNP。离子。研究表明平均粒径为12 nm的分散良好的AgGd BNP，并且在单个晶体中还存在面心立方（FCC）Ag和立方Gd组分。壳聚糖（CS）是一种生物聚合物，作为加帽剂可促进阿霉素（Dox）的生物结合，阿霉素（Boxs）是BNP表面上的一种潜在的抗癌药物。通过与CS结合的pH敏感-将Dox共价缀合到BNP上。体外研究表明，在酸性pH值下，药物释放在生理pH下可忽略不计，而释放速度加快。纳米级AgGd BNP中主体金属的相互特性可提供同步磁共振成像（MRI）和计算机断层扫描（CT）对比性能。此外，Gd在BNP中遗传的顺磁行为表明T ₁和T _{2都存在。}T ₂对比能力。BNP与Dox结合后，可确保生物相容性，并在HeLa细胞中表达稳定的治疗效果。