Obesity is associated with the risk of developing several severe diseases, such as metabolic disorder, diabetes, and heart diseases. Despite wide investigation and trials, a noninvasive obesity therapy is still an important medical unmet need, targeting the abnormal adipose tissue. Here, we developed hyaluronate–hollow gold nanosphere–adipocyte-targeting peptide (HA–HAuNS–ATP) conjugates for the photothermal ablation of adipose tissues. The HA–HAuNS–ATP conjugate could be noninvasively delivered into the skin and effectively target to adipocytes in the subcutaneous. With near-infrared laser illumination, HA–HAuNS–ATP conjugate enabled highly effective photothermal ablation of adipose tissues in C57BL/6 obesity mice. The photoacoustic imaging confirmed the successful transdermal delivery and the photothermal lipolysis of HA–HAuNS–ATP conjugate. Taken together, the transdermal HA–HAuNS–ATP conjugate might have a great potential for noninvasive photothermal lipolysis.

中文翻译：

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有针对性的透明质酸盐-空心金纳米球共轭物，用于抗肥胖光热脂解

肥胖与发生几种严重疾病的风险有关，例如代谢紊乱，糖尿病和心脏病。尽管进行了广泛的研究和试验，但是针对非正常脂肪组织的非侵入性肥胖疗法仍然是医学上尚未满足的重要需求。在这里，我们开发了透明质酸-空心金纳米球-脂肪细胞靶向肽（HA-HAuNS-ATP）偶联物，用于脂肪组织的光热消融。HA-HAuNS-ATP偶联物可以无创地输送到皮肤中，并有效靶向皮下脂肪细胞。通过近红外激光照射，HA–HAuNS–ATP共轭物可对C57BL / 6肥胖小鼠的脂肪组织进行高效的光热消融。光声成像证实了HA–HAuNS–ATP共轭物的成功透皮递送和光热脂解作用。