A novel core–shell nanostructure, hollow copper sulfide nanosphere–doxorubicin (DOX)/graphene oxide (GO) (CuS–DOX/GO), is constructed for the purpose of controlled drug delivery and improved photothermo-chemotherapeutic effect. The CuS–DOX/GO nanocomposite is configured by employing dual photothermal agents, where the core, hollow CuS nanoparticle, acts as delivery-carrier for doxorubicin, and the shell, PEGylated GO nanosheet, prohibits leakage of the drug. DOX can be efficiently loaded onto the hollow CuS nanoparticles, and its subsequent release from CuS–DOX/GO nanocomposite is triggered in a pH- and near-infrared light-dependent manner. Moreover, integration of the two photothermal agents significantly improves the photothermal performance of this system. Ultimately, the combination of phototherapy and chemotherapy based on this system results in a much higher HeLa cell killing efficacy with respect to that for a single chemotherapy mode, as demonstrated by in vitro cytotoxicity tests.

中文翻译：

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空心硫化铜纳米球–阿霉素/氧化石墨烯核–壳纳米复合材料，用于光热化学疗法

一种新型的核-壳纳米结构，空心的硫化铜纳米球-阿霉素（DOX）/氧化石墨烯（GO）（CuS–DOX / GO）的目的是控制药物的输送并改善光热化学疗法的作用。CuS–DOX / GO纳米复合材料通过使用双重光热剂进行配置，其中核心的空心CuS纳米颗粒充当阿霉素的传递载体，而壳PEG化的GO纳米片则阻止了药物的泄漏。DOX可以有效地加载到中空的CuS纳米颗粒上，随后以pH和近红外光依赖的方式触发其从CuS–DOX / GO纳米复合材料中的释放。而且，两种光热剂的集成显着改善了该系统的光热性能。最终，